(SD) uses a customised mixture of acid and base to maximise drug solubility and to generate stirring energy through effervescence which occurs when available acid and base react in the presence of water.

These effects drive very rapid in vivo dissolution which in turn drives gastric emptying as the dissolved drug empties in the co-administered water. The resultant concentrated bolus of drug in solution provides a high concentration gradient to drive rapid absorption across the intestinal wall into the plasma and rapid distribution to the site of action.

Consistent rapid absorption provides for high peak plasma concentrations (Cmax) and early peak plasma concentrations (Tmax). Short Tmax will usually mean reduced time to onset of effect and reduced time to peak effect. Consistent high Cmax reduces the probability of low or sub-therapeutic plasma concentrations which may lead to sub-optimal efficacy.

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