Fast, consistent absorption for every patient, every time

  • In vitro dissolution studies
    • Ultra-fast activated dissolution has been demonstrated for Surge Dose® formulations of a wide range of drugs compared with existing marketed products and conventional formulations
    • Surge Dose® formulations are designed to meet a specification of at least 50-70% dissolution in 3 minutes in non-sink conditions more representative of in vivo conditions.
    • Non-sink methods use conventional dissolution apparatus with a range of dissolution media at different pH, with low or no stirring.
    • Ultra-fast Surge Dose® in vitro dissolution correlates with fast, consistent absorption in vivo compared with conventional products which typically show only 5 -10% in vitro dissolution even after 15 – 20 minutes.
  • Phase I human pharmacokinetic (PK) studies
    • Surge Dose® tablets produce more consistent, faster absorption than standard formulations with mean Tmax values around of 20-30 minutes.
    • Surge Dose® tablets reduce the range of individual subject Tmax values to 15 – 60 minutes compared with 15 minutes to 2 – 3 hours for conventional dosage forms.
  • PK – pharmacodynamic (PD) relationship
    • Modelling PK results for paracetamol (acetaminophen or APAP) indicates that improved, more consistent absorption drives improved efficacy.
    • Faster onset of action confirmed for Surge Dose® in efficacy studies
  • Scale up and stability
    • Our partners have successfully developed several products using the Surge Dose® technology and scaled up to commercial manufacture with satisfactory stability and little impact on COGS

The best for fast, consistent absorption

Many formulation technologies and newer dosage forms have been developed to achieve faster absorption.  However, they still demonstrate significant dose to dose variability even though there may be some reduction in mean and median Tmax values compared with conventional products.  

Dispersible tablets

  • Dispersible tablets avoid the variability associated with in vivo tablet disintegration, but unless the drug dissolves in the water they are dispersed in, they still result in variable absorption.
  • When compared with the brand leader dispersible tablet mixed in water prior to ingestion, Surge Dose® tablets showed significantly faster and more consistent absorption with higher peak plasma concentrations in a fasted PK study.
  • Absorption from the dispersed tablet was highly variable consistent with dispersed drug particles being retained undissolved in the stomach until gastric emptying occurred, often with multiple peaks and Tmax values delayed to 2 hours or more.
  • By comparison, the Surge Dose® tablets swallowed whole, achieved consistently faster and higher peak plasma levels with a mean Tmax value of 19 minutes in the range 15 – 30 minutes.
  • Delayed absorption and low peak plasma concentrations with the dispersible tablet can be associated with slow onset of action and even lack of efficacy.

Liquid filled capsules

  • Absorption from this dosage form relies on shell rupture for release of contents and subsequent drug release and dissolution. 
  • Typically this occurs in the stomach so that absorption from the small intestine is delayed until gastric emptying occurs.

Orally disintegrating tablets (ODTs)

  • Typically ODTs, dispersed in the mouth and swallowed with small volumes of saliva, show variable and often delayed absorption with multiple peaks associated with gastric emptying.

Further Information

Technology Overview
Fast and Consistent Absorption

445 thoughts on “Supporting Evidence”

  1. Pingback: Diversity and inclusion

  2. Pingback: رسوم دراسة ماجستير إدارة الأعمال

  3. Pingback: فرص العمل

  4. Pingback: Community service

  5. Pingback: Marketing courses

  6. Pingback: Graduate programs at future university

  7. Pingback: ما هي افضل الكليات الخاصه

  8. Pingback: لبروتوكولات الوطنية والدولية لكلية الصيدلة بجامعة المستقبل

  9. Pingback: academic plan

  10. Pingback: top university in egypt

  11. Pingback: https://www.kooky.domains/post/decentralized-web3-domains

  12. Pingback: https://www.kooky.domains/post/transferring-ownership-of-a-web3-domain

  13. Pingback: https://www.kooky.domains/post/managing-multiple-web3-domains-tips-and-best-practices

  14. Pingback: https://www.kooky.domains/post/advantages-of-web3-domains-over-traditional-domains

  15. Pingback: ماجستير في إدارة الأعمال في جامعة المستقبل في مصر

  16. Pingback: درجة الماجستير في إدارة الأعمال في القاهرة

  17. Pingback: fue

  18. Pingback: العلوم السياسية

  19. Pingback: كم كلية سياسة واقتصاد في مصر

  20. Pingback: Public administration

  21. Pingback: Social Celebrations for pharmacy students at future university

  22. Pingback: learning methods in pharmacy

  23. Pingback: Department of Pharmacy Practice and Clinical Pharmacy

  24. Pingback: التحصينات

  25. Pingback: احتفالات اجتماعية لطلاب الصيدلة في جامعة المستقبل

  26. Pingback: طب الأسنان الوقائى

  27. Pingback: Professional services in Egypt

  28. Pingback: what is the best department in the College of Engineering

  29. Pingback: Entrepreneurship and Innovation

  30. Pingback: الهندسة الميكانيكية

  31. Pingback: computer science degrees

  32. Pingback: Academic Advising

  33. Pingback: البرامج الاكاديمية ب كلية الحاسبات بجامعة المستقبل بمصر

  34. Pingback: Faculty of Economics and Political Science

  35. Pingback: Faculty expertise

  36. Pingback: adolescents

  37. Pingback: future unversity in egypt news

  38. Pingback: Microbiology and Immunology

  39. Pingback: كلية طب الأسنان

  40. Pingback: Biochemistry

  41. Pingback: قبول الطلاب الدوليين في جامعة المستقبل

  42. Pingback: ما هي الجامعات الخاصة المعتمدة في مصر

  43. Pingback: Application fee for future university

  44. Pingback: Maillot de football

  45. Pingback: Maillot de football

  46. Pingback: Maillot de football

  47. Pingback: Maillot de football

  48. Pingback: Maillot de football

  49. Pingback: Maillot de football

  50. Pingback: Maillot de football

  51. Pingback: Maillot de football

  52. Pingback: Maillot de football

  53. Pingback: Maillot de football

  54. Pingback: Maillot de football

  55. Pingback: Maillot de football

  56. Pingback: Maillot de football

  57. Pingback: Maillot de football

  58. Pingback: Maillot de football

  59. Pingback: Maillot de football

  60. Pingback: Maillot de football

  61. Pingback: SEOSolutionVIP Fiverr

  62. Pingback: SEOSolutionVIP Fiverr

  63. Pingback: parcours d obstacle

  64. Pingback: pec deck inversé

  65. Pingback: pull ups

  66. Pingback: cage ufc

  67. Pingback: prodentim

  68. Pingback: Fiverr Earn

  69. Pingback: Fiverr Earn

  70. Pingback: Fiverr Earn

  71. Pingback: Fiverr Earn

  72. Pingback: Fiverr Earn

  73. Pingback: Fiverr Earn

  74. Pingback: Fiverr Earn

  75. Pingback: Fiverr Earn

  76. Pingback: Fiverr Earn

  77. Pingback: Fiverr Earn

  78. Pingback: Fiverr Earn

  79. Pingback: Lampade a soffitto led al miglior prezzo

  80. Pingback: fiverrearn.com

  81. Pingback: fiverrearn.com

  82. Pingback: fiverrearn.com

  83. Pingback: fiverrearn.com

  84. Pingback: fiverrearn.com

  85. Pingback: fiverrearn.com

  86. Pingback: fiverrearn.com

  87. Pingback: flatbed broker

  88. Pingback: TLI

  89. Pingback: prodentim buy

  90. Pingback: clima hoy

  91. Pingback: clima para hoy

  92. Pingback: fiverrearn.com

  93. Pingback: french bulldog puppies

  94. Pingback: fiverrearn.com

  95. Pingback: fiverrearn.com

  96. Pingback: fiverrearn.com

  97. Pingback: male french bulldog

  98. Pingback: french bulldog vs boston terrier

  99. Pingback: blue eyed french bulldog

  100. Pingback: fluffy frenchie

  101. Pingback: frenchtons

  102. Pingback: exotic bullies

  103. Pingback: micro bully

  104. Pingback: isla mujeres golf cart

  105. Pingback: jute vs sisal rug

  106. Pingback: seo in United Kingdom

  107. Pingback: Do antibiotics damage body cells stromectol 3 mg online?

  108. Pingback: blogging

  109. Pingback: Seo marketing

  110. Pingback: What are 3 symptoms of a parasitic disease stromectol 6 mg?

  111. Pingback: Piano Moving London

  112. Pingback: Piano Moving Quotes

  113. Pingback: What causes blood pressure to rise in the evening scaly leg mite treatment ivermectin?

  114. Pingback: Private universities in Egypt

  115. Pingback: Top university in Egypt

  116. Pingback: Private universities in Egypt

  117. Pingback: How can a man increase his sperm levitra buy?

  118. Pingback: Top university in Egypt

  119. Pingback: Private universities in Egypt

  120. Pingback: Why do my legs seize up at night generic for levitra?

  121. Pingback: Best university in Egypt

  122. Pingback: Top university in Egypt

  123. Pingback: Private universities in Egypt

  124. Pingback: Best university in Egypt

  125. Pingback: Best university in Egypt

  126. Pingback: What are the effects of chronic opioid use on erectile function how does levitra work?

  127. Pingback: golf cart isla mujeres

  128. Pingback: What foods conceive a girl side effects of levitra?

  129. Pingback: french bulldog adoption

  130. Pingback: blue sable french bulldog

  131. Pingback: lilac brindle french bulldog

  132. Pingback: big rope french bulldog

  133. Pingback: Medications - Bridging the Gap between Illness and Wellness substitute for viagra over the counter?

  134. Pingback: crypto news

  135. Pingback: dog accessories

  136. Pingback: zodiac jewelry

  137. Pingback: destin florida weather

  138. Pingback: clima fresno

  139. Pingback: Medications and Skin Protection - Shielding against Environmental Aggressors stromectol for scabies dosage?

  140. Pingback: micro french bulldog

  141. Pingback: Drug Safety and Health - Navigating the Risks and Benefits priligy review?

  142. Pingback: iPhone repair Orange County

  143. Pingback: french bulldog texas for sale

  144. Pingback: Customised bracelet with name

  145. Pingback: best Phone

  146. Pingback: top Samsung phones

  147. Pingback: future university

  148. Pingback: future university

  149. Pingback: Innovative Medications Transforming Healthcare Landscape buy stromectol 12mg?

  150. Pingback: isla mujeres golf cart rental

  151. Pingback: multisbo link alternatif

  152. Pingback: isla mujeres golf cart rentals

  153. Pingback: Does silence hurt an ex Cenforce 50mg ca?

  154. Pingback: Can an enlarged prostate go back to normal order Cenforce?

  155. Pingback: Is there a connection between erectile dysfunction and infertility Cenforce tablet?

  156. Pingback: What is a true love Cenforce 200 sildenafil citrate?

  157. Pingback: seo company in houston

  158. Pingback: wix

  159. Pingback: Drug Trials Show Promise in Fighting Deadly Diseases fildena 50mg oral?

  160. Pingback: How can air quality improvements reduce the health impacts of air pollution buy hydroxychloroquine online without prescription?

  161. Pingback: Medications - Unlocking the Potential for Health Breakthroughs where to buy dapoxetine?

  162. Pingback: bulldogs puppy

  163. Pingback: Fiverr

  164. Pingback: Fiverr.Com

  165. Pingback: FiverrEarn

  166. Pingback: FiverrEarn

  167. Pingback: grey frenchie

  168. Pingback: hydroxychloroquine 200 mg tablet?

  169. Pingback: top university Egypt

  170. Pingback: golf cart rental isla mujeres

  171. Pingback: french bulldog

  172. Pingback: Continuous improvement

  173. Pingback: austin french bulldog

  174. Pingback: oral medication for scabies?

  175. Pingback: Warranty

  176. Pingback: Piano repair specialists

  177. Pingback: Piano relocation experts

  178. Pingback: FUE

  179. Pingback: FUE

  180. Pingback: FUE

  181. Pingback: FUE

  182. Pingback: FUE

  183. Pingback: FUE

  184. Pingback: Packing expertise

  185. Pingback: Organized moving

  186. Pingback: Moving consultation

  187. Pingback: Packing materials

  188. Pingback: Packing materials

  189. Pingback: batmanapollo.ru

  190. Pingback: Activate.BestBuy.AccountOnline.com

  191. Pingback: برنامج ادارة الاعمال بمصر

  192. Pingback: 777

  193. Pingback: Innovative Medications Transforming Healthcare Landscape dapoxetine mexico?

  194. Pingback: wlw.su

  195. Pingback: vxi.su

  196. Pingback: Classic Books 500

  197. Pingback: FiverrEarn

  198. Pingback: nlpvip.ru

  199. Pingback: FiverrEarn

  200. Pingback: russianmanagement.com

  201. Pingback: FiverrEarn

  202. Pingback: Slovo pacana 6 seriya

  203. Pingback: Fiverr.Com

  204. Pingback: Fiverr

  205. Pingback: FiverrEarn

  206. Pingback: Sell Unwanted items online

  207. Pingback: FiverrEarn

  208. Pingback: FiverrEarn

  209. Pingback: site

  210. Pingback: slovo-pacana-6-seriya

  211. Pingback: FiverrEarn

  212. Pingback: manipulyation

  213. Pingback: FiverrEarn

  214. Pingback: How can global efforts contribute to the eradication of infectious diseases like malaria fildena 150 mg?

  215. Pingback: Medications and Sports Injuries - Facilitating Rehabilitation priligy 30 mg fiyat?

  216. Pingback: Coach

  217. Pingback: How long is a course of antibiotics stroР’В­mecР’В­tol for head lice?

  218. Pingback: Emergency Preparedness and Response in Healthcare order stromectol 3mg?

  219. Pingback: Quels sont les signes de l'infidelite cialis generique belgique?

  220. Pingback: FiverrEarn

  221. Pingback: FiverrEarn

  222. Pingback: FiverrEarn

  223. Pingback: FiverrEarn

  224. Pingback: Pornography Australia

  225. Pingback: How can I find out if my medication is available through patient assistance foundations priligy 30?

  226. Pingback: Pupuk terbaik dan terpercaya di pupukanorganik.com

  227. Pingback: Pupuk Organik terpercaya dan terbaik hanya melalui pupukanorganik.com

  228. Pingback: pupuk anorganik cair

  229. Pingback: Pupuk Organik terbaik dan terpercaya di pupukanorganik.com

  230. Pingback: pupuk anorganik cair

  231. Pingback: How many steps should I walk daily to reduce belly fat order Cenforce generic?

  232. Pingback: pupuk anorganik cair

  233. Pingback: Unisex Modern Graphic Tees/Apparel

  234. Pingback: partners

  235. Pingback: Why do doctors hit the chest before CPR furosemide 40mg us?

  236. Pingback: supplements for skin care

  237. Pingback: neurozoom where to buy

  238. Pingback: Why is my inhaler not helping albuterol recall

  239. Pingback: STUDY ABROAD AGENCY IN KOTTAYAM

  240. Pingback: Are bananas good for parasites soolantra ivermectin cream 1

  241. Pingback: glucotrust reviews

  242. Pingback: cachorros de bulldog frances

  243. Pingback: Can you take steroids and have asthma ventolin

  244. Pingback: french bulldog for sale

  245. Pingback: Football

  246. Pingback: FiverrEarn

  247. Pingback: FiverrEarn

  248. Pingback: FiverrEarn

  249. Pingback: viagra over the counter alternative

  250. Pingback: FiverrEarn

  251. Pingback: FiverrEarn

  252. Pingback: Cenforce 50 review video

  253. Pingback: vidalista 500 mg l-arginina

  254. Pingback: live sex cams

  255. Pingback: live sex cams

  256. Pingback: live sex cams

  257. Pingback: live sex cams

  258. Pingback: FiverrEarn

  259. Pingback: FiverrEarn

  260. Pingback: FiverrEarn

  261. Pingback: FiverrEarn

  262. Pingback: FiverrEarn

  263. Pingback: FiverrEarn

  264. Pingback: furosemide 5 mg

  265. Pingback: french bulldog

  266. Pingback: Update Site Error ¹ 654

  267. Pingback: How can I attract my husband to love??

  268. Pingback: Update Site Error ¹ 655

  269. Pingback: What should I do everyday??

  270. Pingback: 354

  271. Pingback: FiverrEarn

  272. Pingback: FiverrEarn

  273. Pingback: FiverrEarn

  274. Pingback: FiverrEarn

  275. Pingback: FiverrEarn

  276. Pingback: FiverrEarn

  277. Pingback: FiverrEarn

  278. Pingback: FiverrEarn

  279. Pingback: FiverrEarn

  280. Pingback: FiverrEarn

  281. Pingback: FiverrEarn

  282. Pingback: FiverrEarn

  283. Pingback: FiverrEarn

  284. Pingback: FiverrEarn

  285. Pingback: FiverrEarn

  286. Pingback: Queen Arwa University

  287. Pingback: FiverrEarn

  288. Pingback: FiverrEarn

  289. Pingback: FiverrEarn

  290. Pingback: FiverrEarn

  291. Pingback: FiverrEarn

  292. Pingback: FiverrEarn

  293. Pingback: სერიალები ქართულად

  294. Pingback: Link

  295. Pingback: seo company new york

  296. Pingback: wix website

  297. Pingback: seo company texas

  298. Pingback: web design

  299. Pingback: agriculture

  300. Pingback: Scientific Research

  301. Pingback: Kampus Islam Terbaik

  302. Pingback: psy

  303. Pingback: FiverrEarn

  304. Pingback: FiverrEarn

  305. Pingback: FiverrEarn

  306. Pingback: FiverrEarn

  307. Pingback: FiverrEarn

  308. Pingback: FiverrEarn

  309. Pingback: kiino4k.ru

  310. Pingback: depresiya

  311. Pingback: film

  312. Pingback: priligy 60 mg para que sirve - Can walking reduce tummy?

  313. Pingback: new 2024

  314. Pingback: chlamydia Azithromycin dose

  315. Pingback: batman apollo

  316. Pingback: film2024

  317. Pingback: 123 Movies

  318. Pingback: laloxeziya-chto-eto-prostymi-slovami.ru

  319. Pingback: albuterol sulfate

  320. Pingback: 000

  321. Pingback: samorazvitiepsi

  322. Pingback: Generator Repair Sheffield

  323. Pingback: slimming tea scam

  324. Pingback: cheap sex cams

  325. Pingback: Tucker Carlson - Vladimir Putin - 2024-02-09 Putin interview summary, full interview.

  326. Pingback: Tucker Carlson - Vladimir Putin

  327. Pingback: nolvadex pct buy

  328. Pingback: cheapest lipitor prices

  329. Pingback: asthalin

  330. Pingback: fluoxetine uses

  331. Pingback: fullersears.com

  332. Pingback: fullersears.com

  333. Pingback: fullersears.com

  334. Pingback: dapoxetine 60 mg india

  335. Pingback: vilitra canada

  336. Pingback: fildena xxx

  337. Pingback: best probiotics for dogs

  338. Pingback: androgel uk

  339. Pingback: albuterol proair

  340. Pingback: porno izle

  341. Pingback: porn

  342. Pingback: child porn

  343. Pingback: porn

  344. Pingback: live sex cams

  345. Pingback: live sex cams

  346. Pingback: live sex cams

  347. Pingback: androgel 1.62

  348. Pingback: buy androgel

  349. Pingback: frt trigger

  350. Pingback: Can the same infection come back after antibiotics HCQS?

  351. Pingback: Creditos fiscales

  352. Pingback: efos y edos

  353. Pingback: Company Registeration

  354. Pingback: 늑대닷컴

  355. Pingback: Slot Online RTP Tinggi

  356. Pingback: One Peace AMV

  357. Pingback: One Peace AMV

  358. Pingback: One Peace AMV

  359. Pingback: nang sydney

  360. Pingback: superslot

  361. Pingback: mobile app development Singapore

  362. Pingback: allgame

  363. Pingback: 918kiss

  364. Pingback: หวย24

  365. Pingback: Cleanser

  366. Pingback: pg slot

  367. Pingback: grandpashabet

  368. Pingback: porno izle

  369. Pingback: leak detection london

  370. Pingback: artificial intelligence lawyer

  371. Pingback: la bonne paye règle

  372. Pingback: cybersécurité

  373. Pingback: bandar slot

  374. Pingback: aplikasi slot terbaru

  375. Pingback: Dating Classes

  376. Pingback: Dating Coach in London

  377. Pingback: east wind spa and hotel

  378. Pingback: resort lake placid

  379. Pingback: grandpashabet

  380. Pingback: dietary supplements

  381. Pingback: megagame

  382. Pingback: weight drops

  383. Pingback: Anonymous

  384. Pingback: 3 408 cheytac

  385. Pingback: 450 bushmaster ammo

  386. Pingback: vidalista 60

  387. Pingback: 300 wsm ammo

  388. Pingback: 44 mag ammo

  389. Pingback: sicarios en españa

  390. Pingback: kamagra priligy

  391. Pingback: cenforce online

  392. Pingback: Cenforce 100

  393. Pingback: SaaS Contract Lawyer

  394. Pingback: itsMasum.Com

  395. Pingback: itsMasum.Com

  396. Pingback: itsMasum.Com

  397. Pingback: itsMasum.Com

  398. Pingback: itsMasum.Com

  399. Pingback: ingénieur informatique salaire

  400. Pingback: certification informatique

  401. Pingback: système dexploitation

  402. Pingback: keylogger

  403. Pingback: FÜHRERSCHEIN SCHWEIZ (CH)

  404. Pingback: Nangs delivery

  405. Pingback: spisok

  406. Pingback: Plombier Tours

  407. Pingback: here

  408. Pingback: itsmasum.com

  409. Pingback: itsmasum.com

  410. Pingback: itsmasum.com

  411. Pingback: chat avenue

  412. Pingback: chat with strangers online

  413. Pingback: teen chat

  414. Pingback: chat with girls

  415. Pingback: chat online

  416. Pingback: boy chat

  417. Pingback: vidalista 10 tablets

  418. Pingback: order Cenforce pill

  419. Pingback: itsmasum.com

  420. Pingback: itsmasum.com

  421. Pingback: itsmasum.com

  422. Pingback: itsmasum.com

  423. Pingback: itsmasum.com

  424. Pingback: oral furosemide 40mg

  425. Pingback: atorvastatin 20

  426. Pingback: is Viagra safe for seniors

  427. Pingback: buy stromectol over the counter

  428. Pingback: albuterol sulfate

  429. Pingback: vidalista 80

  430. Pingback: list

  431. Pingback: cenforce tablets

  432. Pingback: fildena super active kaufen

  433. Pingback: cenforce 100 original

  434. Pingback: vidalista over datum

  435. Pingback: porn

  436. Pingback: vidalista 40

  437. Pingback: joker gaming

  438. Pingback: cenforce d price in india

  439. Pingback: oral Cenforce 100mg

  440. Pingback: Film institutionnel Nantes

  441. Pingback: Film institutionnel Nantes

  442. Pingback: rome jobs

  443. Pingback: job search

  444. Pingback: order Cheap clomid

  445. Pingback: Buying Generic clomid no prescription

Comments are closed.